{"id":2071,"date":"2016-11-18T16:10:40","date_gmt":"2016-11-18T07:10:40","guid":{"rendered":"http:\/\/narebari.com\/community\/?p=2071"},"modified":"2016-11-18T16:10:40","modified_gmt":"2016-11-18T07:10:40","slug":"post-2071","status":"publish","type":"post","link":"https:\/\/narebari.com\/community\/archives\/2071\/post-2071\/","title":{"rendered":"iPS\u7d30\u80de\u304b\u3089\u907a\u4f1d\u6027\u96e3\u8074\u306e\u539f\u56e0\u3068\u306a\u308b\u5185\u8033\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u5f62\u6210\u7d30\u80de\u3092\u4f5c\u88fd"},"content":{"rendered":"<p>\u9806\u5929\u5802\u5927\u5b66\u533b\u5b66\u90e8\u8033\u9f3b\u54bd\u5589\u79d1\u5b66\u8b1b\u5ea7\uff08\u4e3b\u4efb\u6559\u6388\u30fb\u6c60\u7530\u52dd\u4e45\uff09\u306e\u795e\u8c37\u548c\u4f5c\u51c6\u6559\u6388\u3001\u798f\u6c38\u4e00\u6717\u7814\u7a76\u54e1\u3089\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u907a\u4f1d\u6027\u96e3\u80741\uff0a\u306e\u4e2d\u3067\u6700\u3082\u983b\u5ea6\u306e\u9ad8\u3044GJB2\uff08\u30b3\u30cd\u30ad\u30b7\u30f326\uff09\u5909\u7570\u578b\u96e3\u80742\uff0a\u306e\u539f\u56e0\u3068\u306a\u308b\u5185\u8033\u30ae\u30e3\u30c3\u30d7\u7d50\u54083\uff0a\u5f62\u6210\u7d30\u80de\u3092iPS\u7d30\u80de\u304b\u3089\u4f5c\u308b\u6280\u8853\u958b\u767a\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u958b\u767a\u3057\u305f\u65b9\u6cd5\u306b\u3088\u308a\u3001\u3053\u308c\u307e\u3067\u6839\u672c\u7684\u6cbb\u7642\u6cd5\u304c\u5b58\u5728\u3057\u306a\u304b\u3063\u305f\u907a\u4f1d\u6027\u96e3\u8074\u3078\u306e\u85ac\u5264\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3084\u518d\u751f\u533b\u7642\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u96e3\u8074\u7814\u7a76\u306e\u81e8\u5e8a\u5fdc\u7528\u3092\u5b9f\u73fe\u3055\u305b\u308b\u5927\u304d\u306a\u6210\u679c\u3068\u8a00\u3048\u307e\u3059\u3002<br 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\/>\n\u73fe\u5728\u3001\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u30d2\u30c8iPS\u7d30\u80de\u304b\u3089\u5185\u8033\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u5f62\u6210\u7d30\u80de\u306e\u4f5c\u88fd\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306fGJB2\u5909\u7570\u578b\u907a\u4f1d\u6027\u96e3\u8074\u306e\u60a3\u8005\u3055\u3093\u306eiPS\u7d30\u80de\u306e\u6a39\u7acb\u3068\u5206\u5316\u8a98\u5c0e\u306b\u3088\u308a\u3001\u69d8\u3005\u306a\u5909\u7570\u578b\u306b\u5fdc\u3058\u305f\u907a\u4f1d\u6027\u96e3\u8074\u75be\u60a3\u30e2\u30c7\u30eb\u7d30\u80de\u3092\u4f5c\u88fd\u3057\u3001\u85ac\u5264\u958b\u767a\u3084\u518d\u751f\u533b\u7642\u3092\u542b\u3081\u305f\u7dcf\u5408\u7684\u306a\u96e3\u8074\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>\u3010\u7528\u8a9e\u8aac\u660e\u3011<br \/>\n\uff11\uff0a\uff1a\u5148\u5929\u6027\u96e3\u8074\u30fb\u907a\u4f1d\u6027\u96e3\u8074<br \/>\n\u5148\u5929\u6027\u96e3\u8074\u306f\u4e16\u754c\u4e2d\u3067\u51fa\u751f\u51501000\u4eba\u306b1\u4eba\u306e\u5272\u5408\u3067\u767a\u75c7\u3057\u3001\u6700\u3082\u591a\u3044\u5148\u5929\u6027\u969c\u5bb3\u3067\u3042\u308b\u3002\u305d\u306e\u534a\u6570\u4ee5\u4e0a\u306f\u907a\u4f1d\u5b50\u306b\u539f\u56e0\u3092\u6301\u3064\u907a\u4f1d\u6027\u96e3\u8074\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u907a\u4f1d\u6027\u96e3\u8074\u306f\u96e3\u8074\u4ee5\u5916\u306e\u75c7\u72b6\u3092\u4f34\u3046\u75c7\u5019\u7fa4\u6027\u3068\u96e3\u8074\u3092\u4e3b\u75c7\u72b6\u3068\u3059\u308b\u975e\u75c7\u5019\u7fa4\u6027\u306b\u5206\u985e\u3055\u308c\u308b\u3002<\/p>\n<p>\uff12\uff0a\uff1a\u30b3\u30cd\u30ad\u30b7\u30f326\u30fbGJB2\u5909\u7570\u907a\u4f1d\u6027\u96e3\u8074\uff08\u30b3\u30cd\u30ad\u30b7\u30f326\u907a\u4f1d\u5b50\u5909\u7570\u578b\u96e3\u8074\uff09<br \/>\n\u30b3\u30cd\u30ad\u30b7\u30f326\u306f\u907a\u4f1d\u5b50GJB2\uff08GAP JUNCTION PROTEIN, BETA-2\uff09\u306b\u3088\u308a\u5408\u6210\u3055\u308c\u3001\u5185\u8033\u306e\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u3092\u69cb\u6210\u3059\u308b\u4e3b\u8981\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u3064\u3002\u4e16\u754c\u3067\u6700\u3082\u9ad8\u983b\u5ea6\u306b\u691c\u51fa\u3055\u308c\u308b\u907a\u4f1d\u6027\u96e3\u8074\u306e\u539f\u56e0\u56e0\u5b50\u3002 GJB2\u5909\u7570\u907a\u4f1d\u6027\u96e3\u8074\uff08\u30b3\u30cd\u30ad\u30b7\u30f326\u907a\u4f1d\u5b50\u5909\u7570\u578b\u96e3\u8074\uff09\u306f\u3001\u6211\u304c\u56fd\u3067\u306f\u907a\u4f1d\u6027\u96e3\u8074\u306e50\uff05\u4ee5\u4e0a\u3082\u306e\u5272\u5408\u3092\u5360\u3081\u308b\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u3068\u5e38\u67d3\u8272\u4f53\u512a\u6027\u306e\u907a\u4f1d\u5f62\u5f0f\u3092\u6301\u3064\u611f\u97f3\u6027\u96e3\u8074\u3002\u307e\u308c\u306b\u76ae\u819a\u75be\u60a3\u3092\u4f34\u3046\u3082\u306e\u3082\u3042\u308b\u304c\u3001\u4e3b\u306b\u306f\u975e\u75c7\u5019\u7fa4\u6027\u3002<\/p>\n<p>\uff13\uff0a\uff1a\u30ae\u30e3\u30c3\u30d7\u7d50\u5408<br \/>\n\u30b3\u30cd\u30ad\u30b7\u30f3\u306f\u7d30\u80de\u819c\u30676\u500b\u306e\u96c6\u5408\u4f53\u306b\u3088\u308a\u5206\u5b50\u306e\u901a\u308a\u9053\u3092\u4f5c\u308a\u3001\u96a3\u306e\u7d30\u80de\u306e\u96c6\u5408\u4f53\u3068\u9023\u7d50\u3057\u3066\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u3092\u4f5c\u308b\u3002\u3053\u306e\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u306f\u5206\u5b50\u91cf\u7d041000\u4ee5\u4e0b\u306e\u4f4e\u5206\u5b50\u3084\u30a4\u30aa\u30f3\u3092\u6fc3\u5ea6\u52fe\u914d\u306b\u3088\u3063\u3066\u900f\u904e\u3055\u305b\u3001\u7d30\u80de\u9593\u306e\u7269\u8cea\u8f38\u9001\u3092\u53ef\u80fd\u3068\u3059\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u539f\u8457\u8ad6\u6587\u3011<br \/>\n\u30bf\u30a4\u30c8\u30eb\uff1a<br \/>\n\u300cIn vitro models of GJB2-related hearing loss recapitulate Ca2+ transients via a gap junction characteristic of developing cochlea\u300d<\/p>\n<p>\u8457\u8005\uff1a<br \/>\nIchiro Fukunaga, Ayumi Fujimoto, Kaori Hatakeyama, Toru Aoki, Atena Nishikawa,<br \/>\nTetsuo Noda, Osamu Minowa, Nagomi Kurebayashi, Katsuhisa Ikeda, Kazusaku Kamiya<\/p>\n<p>\u63b2\u8f09\u8a8c\uff1a Stem Cell Reports, 2016<\/p>\n<p>DOI: 10.1016\/j.stemcr.2016.10.005<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff08AMED\uff09\u96e3\u6cbb\u6027\u75be\u60a3\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d\uff08\u7814\u7a76\u958b\u767a\u4ee3\u8868\u8005 \u795e\u8c37\u548c\u4f5c\uff09\u3001\u6587\u90e8\u79d1\u5b66\u7701\u79d1\u5b66\u7814\u7a76\u8cbb \u57fa\u76e4\u7814\u7a76B\uff08\u8ab2\u984c\u756a\u53f725293351 \uff09\u3001\u57fa\u76e4\u7814\u7a76 C \uff08\u8ab2\u984c\u756a\u53f725462653 \uff09\u3001\u6311\u6226\u7684\u840c\u82bd\u7814\u7a76\uff08\u8ab2\u984c\u756a\u53f716693312 \uff09\u3001\u82e5\u624b\u7814\u7a76B\uff08\u8ab2\u984c\u756a\u53f715K20229 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target=\"_blank\">\u3053\u3061\u3089<\/a><\/p>\n<p>\u5f15\u7528\u5143\uff1a<a onmousedown=\"ga('send', 'event', 'post-click', 'ct-iPS\u7d30\u80de\u304b\u3089\u907a\u4f1d\u6027\u96e3\u8074\u306e\u539f\u56e0\u3068\u306a\u308b\u5185\u8033\u30ae\u30e3\u30c3\u30d7\u7d50\u5408\u5f62\u6210\u7d30\u80de\u3092\u4f5c\u88fd','http:\/\/prtimes.jp\/main\/html\/rd\/p\/000000011.000021495.html');\" href=\"http:\/\/prtimes.jp\/main\/html\/rd\/p\/000000011.000021495.html\" target=\"_blank\">PR times<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9806\u5929\u5802\u5927\u5b66\u533b\u5b66\u90e8\u8033\u9f3b\u54bd\u5589\u79d1\u5b66\u8b1b\u5ea7\uff08\u4e3b\u4efb\u6559\u6388\u30fb\u6c60\u7530\u52dd\u4e45\uff09\u306e\u795e\u8c37\u548c\u4f5c\u51c6\u6559\u6388\u3001\u798f\u6c38\u4e00\u6717 &#8230; 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